Serotonin Loss May Drive Cognitive Decline

 In Alzheimer's Disease

Studies have shown with normal aging and Alzheimer’s disease (AD) that serotonin degeneration occurs. The new study suggests that the serotonin system is affected in mild cognitive impairment (MCI), the early stages before dementia.

The study included 28 individuals with MCI and 26 healthy individuals who are cognitively normal. They underwent numerous neuroimaging. The study showed that there is reduction in serotonin transporter levels in the cortex and limbic areas for patients with MCI. Lower levels were associated with worse performance on verbal and visual memory in MCI patients.

These results suggest that the serotonin system may be an effective target for treatment. Studies to determine serotonin degeneration may be involved in the transition from MCI to dementia and the relationship to AD pathology, beta amyloid and tau.

The new study is published in Neurobiology of Disease, 2017: 105: 33-41.

Serotonin loss may drive cognitive decline – Medscape – Aug 22, 2017.

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